{"id":5932,"date":"2026-03-18T23:26:50","date_gmt":"2026-03-18T20:26:50","guid":{"rendered":"https:\/\/neoberidhaber.kahveciyazilim.com\/?p=5932"},"modified":"2026-03-18T23:27:01","modified_gmt":"2026-03-18T20:27:01","slug":"okyanustan-gelen-kesif-insan-omru-200-yila-uzayabilir","status":"publish","type":"post","link":"https:\/\/neoberidhaber.kahveciyazilim.com\/index.php\/2026\/03\/18\/okyanustan-gelen-kesif-insan-omru-200-yila-uzayabilir\/","title":{"rendered":"Okyanustan gelen ke\u015fif: \u0130nsan \u00f6mr\u00fc 200 y\u0131la uzayabilir"},"content":{"rendered":"\n

Modern t\u0131p<\/strong>, insan \u00f6mr\u00fcn\u00fcn biyolojik s\u0131n\u0131rlar\u0131n\u0131 zorlayacak bir ke\u015ffe imza att\u0131. Nature Dergisi’<\/strong>nde yay\u0131mlanan ve geni\u015f yank\u0131 uyand\u0131ran ara\u015ft\u0131rmaya g\u00f6re, Gr\u00f6nland balinalar\u0131n\u0131n (Bowhead) genetik haritas\u0131, uzun ve hastal\u0131ks\u0131z bir ya\u015fam\u0131n anahtar\u0131n\u0131 bar\u0131nd\u0131r\u0131yor. Bilim insanlar\u0131, bu dev memelilerin DNA hasarlar\u0131n\u0131 onarma konusundaki ola\u011fan\u00fcst\u00fc yetene\u011fini insan h\u00fccrelerine aktarman\u0131n yollar\u0131n\u0131 ar\u0131yor. Ara\u015ft\u0131rma sonu\u00e7lar\u0131, do\u011fru genetik m\u00fcdahalelerle insan \u00f6mr\u00fcn\u00fcn bug\u00fcnk\u00fc ortalamas\u0131n\u0131n iki kat\u0131na \u00e7\u0131kabilece\u011fi \u00f6ng\u00f6r\u00fcs\u00fcn\u00fc destekliyor.<\/p>\n\n\n\n

DNA ONARIMINDA DEVR\u0130M: CIRBP PROTE\u0130N\u0130<\/h3>\n\n\n\n

Rochester \u00dcniversitesi’nden Profes\u00f6r Vera Gorbunova ve Profes\u00f6r Andrei Seluanov liderli\u011findeki ekip, balinalar\u0131n genetik yap\u0131s\u0131nda CIRBP adl\u0131 bir proteinin normalden 100 kat daha fazla oldu\u011funu saptad\u0131. H\u00fccrelerin yap\u0131 ta\u015f\u0131 olan DNA’da meydana gelen \u00e7ift zincir k\u0131r\u0131klar\u0131, ya\u015flanman\u0131n ve kanser gibi \u00f6l\u00fcmc\u00fcl hastal\u0131klar\u0131n temel tetikleyicisi olarak kabul ediliyor. CIRBP proteini ise bu k\u0131r\u0131klar\u0131 mucizevi bir h\u0131zla onararak h\u00fccrenin ya\u015flanmas\u0131n\u0131 durduruyor. Balinalar\u0131n y\u00fczy\u0131llarca hayatta kalmas\u0131n\u0131 sa\u011flayan bu “genetik tamir kiti”, insan h\u00fccreleri i\u00e7in de yeni bir umut kayna\u011f\u0131 haline geldi. Profes\u00f6r Gorbunova, \u00e7al\u0131\u015fman\u0131n insan \u00f6mr\u00fcn\u00fcn tipik s\u0131n\u0131rlar\u0131n\u0131n \u00f6tesine ge\u00e7ebilece\u011fini kan\u0131tlad\u0131\u011f\u0131n\u0131 ifade ediyor.<\/p>\n\n\n\n

\"Image\"\/<\/figure>\n\n\n\n

‘KANSERE BA\u011eI\u015eIKLIK’ KAZANAN DEV MEMEL\u0130LER<\/h3>\n\n\n\n

Bilim d\u00fcnyas\u0131n\u0131n uzun s\u00fcredir \u00fczerinde durdu\u011fu bir paradoks olan “b\u00fcy\u00fck hayvanlar\u0131n neden daha az kanser oldu\u011fu” sorusu da bu \u00e7al\u0131\u015fmayla yan\u0131t buldu. Normal \u015fartlarda h\u00fccre say\u0131s\u0131 artt\u0131k\u00e7a kanser riskinin de artmas\u0131 beklenirken, balinalar ve filler bu kural\u0131 bozuyor. Ara\u015ft\u0131rmac\u0131lar, bu dev memelilerin kanser h\u00fccreleri hen\u00fcz olu\u015fma a\u015famas\u0131ndayken genlerini onaracak \u015fekilde evrimle\u015ftiklerini belirtiyor. Gr\u00f6nland balinalar\u0131ndan al\u0131nan doku \u00f6rnekleri \u00fczerinde yap\u0131lan incelemeler, CIRBP proteininin h\u00fccreyi adeta “kanser ge\u00e7irmez” hale getirdi\u011fini kan\u0131tl\u0131yor. Bu savunma mekanizmas\u0131n\u0131n insanlara entegre edilmesi, onkoloji alan\u0131nda en b\u00fcy\u00fck bulu\u015flardan biri olarak nitelendiriliyor.<\/p>\n\n\n\n

SO\u011eUK DU\u015e VE GELECEK STRATEJ\u0130LER\u0130: GENET\u0130K M\u0130RAS NASIL TET\u0130KLEN\u0130R?<\/h3>\n\n\n\n

Ara\u015ft\u0131rman\u0131n bir di\u011fer \u00e7arp\u0131c\u0131 bulgusu ise CIRBP proteininin \u00fcretimi ile \u00e7evre ko\u015fullar\u0131 aras\u0131ndaki ba\u011flant\u0131 oldu. Profes\u00f6r Seluanov, s\u0131cakl\u0131k d\u00fc\u015ft\u00fc\u011f\u00fcnde v\u00fccudun bu proteini \u00fcretme h\u0131z\u0131n\u0131n artt\u0131\u011f\u0131n\u0131 saptad\u0131. Ancak, insanlarda bu tepkiyi tetiklemek i\u00e7in gereken so\u011fukluk seviyesi hen\u00fcz tam olarak bilinmiyor. Uzmanlar, laboratuvar ortam\u0131nda bu yolu aktif hale getirecek ila\u00e7 stratejileri \u00fczerinde \u00e7al\u0131\u015f\u0131rken, ya\u015fam tarz\u0131 de\u011fi\u015fikliklerinin de etkili olabilece\u011fini belirtiyor. Profes\u00f6r Gorbunova, v\u00fccuttaki mevcut CIRBP aktivitesini art\u0131rmak i\u00e7in “so\u011fuk du\u015f almak” gibi y\u00f6ntemlerin ke\u015ffedilmeye de\u011fer bir alan oldu\u011funa dikkat \u00e7ekiyor.<\/p>\n\n\n\n

Kaynak: Cumhuriyet Gazetesi <\/a><\/strong><\/p>\n\n\n

<\/div>

Emine Tan<\/p><\/div><\/div>\n\n\n

G\u00fcncelleme Tarihi:<\/strong> Mart 18, 2026 23:24<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"Bilim d\u00fcnyas\u0131, Gr\u00f6nland balinalar\u0131n\u0131n 200 y\u0131l\u0131 a\u015fan \u00f6m\u00fcrlerinin s\u0131rr\u0131n\u0131 \u00e7\u00f6zmeyi ba\u015fard\u0131. Rochester \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131, balinalardaki \u00f6zel bir proteinin DNA onar\u0131m mekanizmas\u0131n\u0131 tetikleyerek insanlarda kanser ve ya\u015fl\u0131l\u0131\u011fa ba\u011fl\u0131 hastal\u0131klar\u0131n tedavisinde devrim yaratabilece\u011fini vurguluyor.","protected":false},"author":1,"featured_media":5931,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"csco_display_header_overlay":false,"csco_singular_sidebar":"","csco_page_header_type":"","csco_page_load_nextpost":"","csco_post_video_location":[],"csco_post_video_location_hash":"","csco_post_video_url":"","csco_post_video_bg_start_time":0,"csco_post_video_bg_end_time":0,"footnotes":""},"categories":[1,16],"tags":[],"class_list":["post-5932","post","type-post","status-publish","format-standard","has-post-thumbnail","category-genel","category-yasam","cs-entry","cs-video-wrap"],"_links":{"self":[{"href":"https:\/\/neoberidhaber.kahveciyazilim.com\/index.php\/wp-json\/wp\/v2\/posts\/5932","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neoberidhaber.kahveciyazilim.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neoberidhaber.kahveciyazilim.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neoberidhaber.kahveciyazilim.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neoberidhaber.kahveciyazilim.com\/index.php\/wp-json\/wp\/v2\/comments?post=5932"}],"version-history":[{"count":1,"href":"https:\/\/neoberidhaber.kahveciyazilim.com\/index.php\/wp-json\/wp\/v2\/posts\/5932\/revisions"}],"predecessor-version":[{"id":5933,"href":"https:\/\/neoberidhaber.kahveciyazilim.com\/index.php\/wp-json\/wp\/v2\/posts\/5932\/revisions\/5933"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neoberidhaber.kahveciyazilim.com\/index.php\/wp-json\/wp\/v2\/media\/5931"}],"wp:attachment":[{"href":"https:\/\/neoberidhaber.kahveciyazilim.com\/index.php\/wp-json\/wp\/v2\/media?parent=5932"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neoberidhaber.kahveciyazilim.com\/index.php\/wp-json\/wp\/v2\/categories?post=5932"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neoberidhaber.kahveciyazilim.com\/index.php\/wp-json\/wp\/v2\/tags?post=5932"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}