Abdullah G\u00fcl \u00dcniversitesi (AG\u00dc) Bilgisayar M\u00fchendisli\u011fi \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. Burcu Bak\u0131r G\u00fcng\u00f6r, ba\u011f\u0131rsak floras\u0131n\u0131 yapay zekayla analiz ederek kolon kanseri tan\u0131 ve tedavisine yard\u0131mc\u0131 olmay\u0131 hedefliyor.<\/p>\n\n\n\n
Sabanc\u0131 \u00dcniversitesi Biyoloji Bilimleri ve Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc mezunu G\u00fcng\u00f6r, y\u00fcksek lisans\u0131n\u0131 ABD’de Georgia Teknoloji Enstit\u00fcs\u00fc’nde biyoinformatik alan\u0131nda tamamlad\u0131.”Kolorektal Kanserin Taksonomik Biyo-mark\u00f6rlerinin \u0130nsan Ba\u011f\u0131rsak Mikrobiyotas\u0131ndan Ke\u015ffi” konulu \u00e7al\u0131\u015fmas\u0131yla 2022 y\u0131l\u0131nda L’Oreal T\u00fcrkiye ve UNESCO taraf\u0131ndan Y\u0131l\u0131n Gen\u00e7 Bilim Kad\u0131n\u0131 \u00d6d\u00fcl\u00fc’ne lay\u0131k g\u00f6r\u00fclen ve hikayesi “Bilimin \u0130zinde Cesur T\u00fcrk Kad\u0131nlar\u0131n\u0131n Hikayesi” adl\u0131 kitapta yay\u0131mlanan G\u00fcng\u00f6r, 2025 y\u0131l\u0131n\u0131n aral\u0131k ay\u0131nda ise Uluslararas\u0131 Elektrik ve Elektronik M\u00fchendisleri Enstit\u00fcs\u00fcnden Ara\u015ft\u0131rma Te\u015fvik \u00d6d\u00fcl\u00fc ald\u0131.<\/p>\n\n\n\n
“\u00d6d\u00fcll\u00fc \u00e7al\u0131\u015fma kapsam\u0131nda kolon kanseri tan\u0131 ve tedavisinde yapay zekadan faydalanan G\u00fcng\u00f6r, 9 \u00fclkeden toplanan haz\u0131r veri setlerinden yararland\u0131.<\/p>\n\n\n\n
Bu veri setlerini kullanarak yeni bir makine \u00f6\u011frenmesi (Daha fazla veri t\u00fckettik\u00e7e \u00f6\u011frenen ve geli\u015fen sistemler olu\u015fturmaya odaklanan yapay zekan\u0131n bir alt k\u00fcmesidir) modeli geli\u015ftirip, yapay zekayla ba\u011f\u0131rsak floras\u0131ndaki bakteri ve enzimleri s\u0131n\u0131fland\u0131ran G\u00fcng\u00f6r, \u00e7al\u0131\u015fmayla kolon kanseri tan\u0131 ve tedavisine yard\u0131mc\u0131 olmay\u0131 ama\u00e7l\u0131yor.<\/p>\n\n\n\n
G\u00fcng\u00f6r, AA muhabirine, ba\u011f\u0131rsak floras\u0131n\u0131n kanser \u00fczerindeki etkisini ara\u015ft\u0131rd\u0131klar\u0131n\u0131 s\u00f6yledi.<\/p>\n\n\n\n
Herkesin ba\u011f\u0131rsa\u011f\u0131nda ya\u015fayan canl\u0131lar\u0131n oldu\u011funu belirten G\u00fcng\u00f6r, “Bunlar Samanyolu Galaksisi’ndeki y\u0131ld\u0131zlar\u0131n say\u0131s\u0131 kadar. Her birimizin v\u00fccudunda ve ba\u011f\u0131rsaklar\u0131nda yararl\u0131 ve zararl\u0131 bakteriler ya\u015f\u0131yor. Bunlar bir denge halinde ya\u015f\u0131yor. Sa\u011fl\u0131kl\u0131 bir insan profilinde birbirleriyle bar\u0131\u015f\u0131k bir d\u00fczen i\u00e7indeler.” dedi.<\/p>\n\n\n\n
“Kolon kanseri \u00e7al\u0131\u015fmam\u0131zda 4 \u00f6nemli bakteri ve 15 enzim bulduk<\/p>\n\n\n\n
“Kanserin olu\u015fumunu anlamak i\u00e7in sa\u011fl\u0131kl\u0131 ve hasta grubunun ba\u011f\u0131rsak floras\u0131n\u0131n kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131n\u0131 dile getiren G\u00fcng\u00f6r, \u015f\u00f6yle devam etti:<\/p>\n\n\n\n
“Hasta grupta ba\u011f\u0131rsakta ne olmu\u015f, bu flora nas\u0131l bozulmu\u015f, hangi bakteriler artm\u0131\u015f, azalm\u0131\u015f, bunu anlamak i\u00e7in bir yapay zeka y\u00f6ntemi geli\u015ftirdik. Yapt\u0131\u011f\u0131m\u0131z ba\u015fka bir \u015fey de sadece bakteri ve vir\u00fcsler de\u011fil, onlar\u0131n \u00fcrettikleri enzimler, biyolojik etkilenen yolaklar var. Biz b\u00fct\u00fcnc\u00fcl bir yakla\u015f\u0131mla gidiyoruz. Ba\u011f\u0131rsak floras\u0131ndaki de\u011fi\u015fen hem bakteri vir\u00fcs dengesini hem burada \u00fcretilen enzimleri, yolaklar\u0131 bir arada analiz ediyoruz. Olas\u0131l\u0131ksal olarak d\u00fc\u015f\u00fcn\u00fcrseniz 1500-2000’den fazla \u00e7e\u015fit bakteri t\u00fcr\u00fc var ama siz bunlardan en \u00e7ok etkilenen 5-10 taneyi bulabilirseniz bunu d\u0131\u015far\u0131dan verebilirsiniz. Kolon kanseri \u00e7al\u0131\u015fmam\u0131zda 4 \u00f6nemli bakteri ve 15 enzim bulduk.<\/p>\n\n\n\n
“Bulduklar\u0131 bakteri ve enzimlerin hastay\u0131 sa\u011fl\u0131kl\u0131 insandan ay\u0131rt etti\u011fini anlatan G\u00fcng\u00f6r, “Birinin ba\u011f\u0131rsa\u011f\u0131na bakt\u0131\u011f\u0131m\u0131zda kolon kanseri midir, de\u011fil midir, bunu anlamak i\u00e7in bu 4 bakteri ba\u011f\u0131rsak floras\u0131nda artm\u0131\u015f m\u0131, azalm\u0131\u015f m\u0131, beklenen seviyeden farkl\u0131 m\u0131, buna bakarak hem tan\u0131ya katk\u0131da bulunabiliriz hem de tedavide o artan\u0131 azaltmaya, azalan\u0131 art\u0131rmaya y\u00f6nelik diyet de\u011fi\u015fiklikleri yap\u0131p tedaviyi destekleyebiliriz.” \u015feklinde konu\u015ftu.<\/p>\n\n\n\n
G\u00fcng\u00f6r, ba\u011f\u0131rsakta genetik de\u011fi\u015fiklik tespit edildi\u011finde geriye d\u00f6n\u00fcp DNA’y\u0131 tamir etmenin \u00e7ok kolay olmad\u0131\u011f\u0131n\u0131 ama ba\u011f\u0131rsak floras\u0131ndaki bir farkl\u0131l\u0131\u011f\u0131n diyet de\u011fi\u015fikli\u011fi ve probiyotik kullan\u0131m\u0131yla ki\u015fiyi normal profile yakla\u015ft\u0131rabilece\u011fini kaydetti.<\/p>\n\n\n\n